“Between atom and cell”
ARBRE focuses on molecular-scale biophysics.
This is a dynamic interdisciplinary field that aims to study biological macromolecules and assemblies as a whole, at an intermediate level between atomic-resolution structural descriptions and cellular-level observations (“Between atom and cell”), with significant applications in biomedicine and drug discovery.
It has a well-defined identity of its own, which interfaces with several other closely-related methodological fields.
ARBRE aims to ally and synergize the power
of a wide diversity of technological approaches.
Technologies of expertise of ARBRE members
(non-exhaustive and continuously evolving list)
Advanced spectroscopies
- CD: Circular Dichroism
- EPR: Electron Paramagnetic Resonance
- Fluorescence Microscopy (FRET, FLIM, FCS, …)
- Fluorescence Spectroscopy (including fluorescence anisotropy)
- FTIR: Fourier Transform Infrared Spectroscopy
- LD: Linear Dichroism
- Mössbauer spectroscopy
- MST: Micro Scale Thermophoresis
- Raman spectroscopy
Hydrodynamics
- AUC: Analytical Ultra Centrifugation
- DLS: Dynamic Light Scattering
- FIDA: Flow-Induced Dispersion Analysis
- MDS: Microfluidic Diffusional Sizing
- SAXS: Small Angle X-ray Scattering
- SEC-MALS: Size Exclusion Chromatography – Multi-Angle Light Scattering
- Second Harmonic Scattering
Real-time Biosensing
- BLI: BioLayer Interferometry
- GCI: Grating-Coupled Interferometry
- QCM: Quartz Crystal Microbalance
- Rapid Kinetic approaches: Stopped and continuous flow, T-Jump, Rapid freeze-quench
- SPR: Surface Plasmon Resonance
Single-Molecule approaches
- AFM: Atomic Force Microscopy
- Magnetic tweezers
- MP: Mass Photometry
- Optical Tweezers
- Single-molecule FRET
Thermodynamics
- DSC: Differential Scanning Calorimetry
- DSF: Differential Scanning Fluorimetry
- ITC: Isothermal Titration Calorimetry